Senior Research Officer, CIDRI AFRICA and Division of Medical Virology, Department of Pathology
Associate Member, Institute of Infectious Disease and Molecular Medicine (IDM), Faculty of Health Sciences, University of Cape Town
Current research interests include the investigation of : 1) Mycobacterium tuberculosis (Mtb)-specific T cell responses across the spectrum of tuberculosis infection and 2) the impact of HIV-co-infection on host Immune response against Mtb.
Key Expertise: T cell immunology, HIV/TB co-infection, Flow cytometry.
Sallin MA*, Kauffman KD*, Riou C, Du Bryn E, Foreman TW, Sakai S, Hoft SG, Myers T, Gardins P, Sher A, Moore R, Wilder-Kofie T, Moore IN, Sette A, Lindestam Arlehamn C, Wilkinson RJ and Barber DL. CD153 expression by CD4 T cells is required for control of pulmonary Mycobacterium tuberculosis infection. 2018. Nature Microbiology 3:1198-1205. doi: 10.1038/s41564-018-0231-6. PMID: 30202016. (*Co 1st author).
Esmail H*, Riou C*, du Bruyn E, Lai RPJ, Harley YXR, Meintjes G, Wilkinson KA and Robert J. Wilkinson RJ. The Immune Response to Mycobacterium tuberculosis in HIV-1-Coinfected Persons. 2018. Annu Rev Immunol. 36:603-638. (*Co 1st author). doi: 10.1146/annurev-immunol-042617-053420
Riou C, Berkowitz N, Goliath R, Burgers WA and Wilkinson RJ. Analysis of the phenotype of Mtb-specific CD4+ T cells to discriminate latent from active tuberculosis in HIV-uninfected and HIV-infected individuals. 2017. Front Immunol. 8:968. doi: 10.3389/fimmu.2017.00968
Strickland N, Müller TL, Berkowitz N, Goliath R, Carrington MN, Wilkinson RJ, Burgers WA and Riou C. Characterization of Mycobacterium tuberculosis-specific cells using MHC class II tetramers reveals phenotypic differences related to HIV infection and TB disease. 2017. J Immunol doi: 10.4049/jimmunol.1700849.
Wilkinson KA, Oni T, Gideon HP, Rene Goliath R, Robert J. Wilkinson RJ and Riou C. Activation profile of Mycobacterium tuberculosis-specific CD4+ T cells reflects disease activity, irrespective of HIV status. 2016. AJRCCM. 193:1307-1310.
Riou C, Strickland N, Soares AP, Corleis B, Kwon D, Wherry E.J, Wilkinson R.J and Burgers WA. HIV skews the lineage-defining transcriptional profile of Mycobacterium tuberculosis-specific CD4+ T cells. 2016. J Immunol. 196:3006-3018.
Riou C*, Tanko RF*, Soares AP, Masson L, Werner L, Garrett NJ, Samsunder N, Abdool Karim Q, Abdool Karim SS and Burgers WA. Restoration of CD4+ responses to co-pathogens in HIV-infected individuals on antiretroviral therapy is dependent on T cell memory phenotype. 2015. J Immunol. 195:2273-81. (*Co 1st author).
Clinical Infectious Diseases Research Initiative
Room WBN 2.09
Institute of Infectious Disease and Molecular Medicine
UCT Faculty of Health Sciences