Prof and Head of Department of Integrative Biomedical Sciences, University of Cape Town; Fellow of Royal Society of South Africa; Fellow of UCT; Member of ASSAf.
Main areas of research/expertise:
Protein biochemistry, protease inhibitor design, enzyme structure-function relationships, ectodomain shedding of angiotensin-converting enzyme.
PhD, 1994, on the synthesis and metabolism of bilirubin. Went on to do a postdoctoral fellowship at Harvard Medical School where he started his research on angiotensin-converting enzyme (ACE), a protein that plays a key role in blood pressure regulation. In 2003 he was awarded a Wellcome Trust International Senior Research Fellowship for his work on ACE. His research interests include: structure-function aspects of ACE; design and synthesis of novel domain-selective ACE inhibitors; and the processing of the membrane-anchored proteins. He has published over 110 peer-reviewed papers and 5 patents, and has trained more than 35 students at PhD and MSc levels. He currently holds a NRF B1 rating. Together with colleagues in the US and UK, he founded a spin-off company AngioDesign Ltd.
Selected recent publications:
Cozier GE, Schwager SL, Sharma RK, Chibale K, Sturrock ED, Acharya KR (2018). Crystal structures of sampatrilat and sampatrilat-Asp in complex with human ACE - a molecular basis for domain selectivity. FEBS J. 285(8):1477-1490.
Abrie JA, Moolman WJA, Cozier GE, Schwager SL, Acharya KR, Sturrock ED (2018). Investigation into the mechanism of homo- and heterodimerization of Angiotensin-Converting Enzyme. Mol Pharmacol. 93(4):344-354.
Fienberg S, Cozier GE, Acharya KR, Chibale K, Sturrock ED (2018). The Design and Development of a Potent and Selective Novel Diprolyl Derivative That Binds to the N-Domain of Angiotensin-I Converting Enzyme. J Med Chem. 11;61(1):344-359.
Ramasamy V, Mayosi BM, Sturrock ED, Ntsekhe M. (2018) Established and novel pathophysiological mechanisms of pericardial injury and constrictive pericarditis. World J Cardiol. 10(9):87-96, Review.
Sharma, R.K., Espinoza-Moraga, M., Poblete, H., Douglas, R.G., Sturrock, E.D., Caballero, J., Chibale, K. The Dynamic Nonprime Binding of Sampatrilat to the C-Domain of Angiotensin-Converting Enzyme. Journal of Chemical Information and Modeling (2016) 56(12):2486-2494
Conrad, N., Schwager, S.L.U., Carmona, A.K., Sturrock, E.D. The effect of structural motifs on the ectodomain shedding of human angiotensin-converting enzyme. Biochemical and Biophysical Research Communications (2016) 481,02-Jan,111-116
Lubbe, L., Sewell, B.T., Sturrock, E.D. The influence of angiotensin converting enzyme mutations on the kinetics and dynamics of N-domain selective inhibition. FEBS Journal (2016) 283(21):3941-3961
Larmuth, K.M., Masuyer, G., Douglas, R.G., Schwager, S.L., Acharya, K.R., Sturrock, E.D. Kinetic and structural characterization of amyloid-β peptide hydrolysis by human angiotensin-1-converting enzyme. FEBS Journal (2016) 283(6):1060-1076
Wernher and Beit North Building Level 3
Faculty of Health Sciences
University of Cape Town