Lecturer, Division of Medical Biochemistry & Structural Biology, Dept. of Integrative Biomedical Sciences
Associate Member, Institute of Infectious Disease and Molecular Medicine (IDM), Faculty of Health Sciences, UCT
Identification and characterization of host factors modulating early steps in HPV infection.
Characterisation of KSHV-driven pathologies and disease outcome in HIV-infected patients in South Africa.
The role of surfactant protein A in immunity to viral infections of the genital tract.
Investigations into the immuno-enhancing effects of garlic and garlic organosulfur compounds in the prevention of cancer.
KEY EXPERTISE: Oncogenic viruses, host-pathogen interactions, cancer biology
Blumenthal MJ, Schutz C, Meintjes G, Mohamed Z, Mendelson M, Ambler JM, Whitby D, Mackelprang RD, Carse S, Katz AA and Schäfer G (2018). EPHA2 sequence variants are associated with susceptibility to Kaposi's sarcoma-associated herpesvirus infection and Kaposi's sarcoma prevalence in HIV-infected patients. Cancer Epidemiology 56:133-139.
Jacobs BA, Chetty A, Horsnell WG, Schäfer G, Prince S and Smith KA (2018). Hookworm exposure decreases human papillomavirus uptake and cervical cancer migration through systemic regulation of epithelial-mesenchymal transition marker expression. Sci Rep 8(1): 11547.
Schäfer G, Graham LM, Lang D, Blumenthal MJ, Bergant Marušič M and Katz AA (2017). Vimentin modulates infectious internalisation of HPV16 pseudovirions. J Virol 91(16):e00307-17.
Blumenthal MJ, Ujma S, Katz AA and Schäfer G (2017). The role of diabetes type II for the development of pathogen-associated cancers in the face of the HIV/AIDS epidemic. Front Microbiol 8:2368.
Ujma S, Horsnell WG, Katz AA, Clark HW and Schäfer G (2017). Non-Pulmonary Immune Functions of Surfactant Proteins A and D. J Innate Immun 9(1):3-11.
Schäfer G, Blumenthal and Katz AA (2015). Interaction of human tumour viruses with host cell surface receptors and cell entry. Viruses 7(5):2592-2617.
Schäfer G and Kaschula CH (2014). The Immunomodulation and Anti-Inflammatory Effects of Garlic Organosulfur Compounds in Cancer Chemoprevention. Anticancer Agents Med Chem 14(2):233-240.
Schäfer G, Kabanda S, van Rooyen B, Bergant M, Banks L and Parker MI (2013). The role of inflammation in HPV infection of the oesophagus. BMC Cancer 13:185.
Schäfer G, Guler R, Murray G, Brombacher F, Brown GD (2009). The Role of Scavenger Receptor B1 in Infection with Mycobacterium tuberculosis in a Murine Model. PLoS One 4(12):e8448.
Schäfer G, Jacobs M, Wilkinson RJ, Brown GD (2009). Non-opsonic recognition of Mycobacterium tuberculosis by phagocytes. J Innate Immun 1:231-243.
Schäfer G, McEvoy C, Patterton HG (2008). The Saccharomyces cerevisiae linker histone Hho1p is essential for chromatin compaction in stationary phase and is displaced by transcription. Proc Natl Acad Sci 105(39):14838-14843.
Room N2.02, Wernher & Beit Building North
Faculty of Health Sciences
University of Cape Town