The Institute comprises 33 Full and 14 Associate Members, with 16 Affiliate Members from departments within the University of Cape Town, and 17 Adjunct Members based nationally or internationally.
Research in the IDM is led by the Full and Associate Members, either working independently with their own research groups or in larger groups led by more than one Member. The Members may also collaborate with Affiliate or Adjunct Members.
Overall, there are more than 30 research groups. These include 3multi-investigator groups that operate principally in the TB/HIV space, 2 extramural research units of the South African Medical Research Council and a number of other research entities, 6 Research Chairs awarded under the National Research Foundation's South African Research Chairs Initiative (SARChI), and further areas of research foci led by individual Members.
As a collective, the research groups include over 300 research officers and laboratory, clinical, field site and administrative support staff, 230 Masters and PhD students registered in any year, and 80 or more Postdoctoral Fellows.