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Dr. Joseph Valentino Raimondo MBChB (Cape Town) MSc (Oxford) DPhil Neuroscience (Oxford)

Neurophysiology Research Group

Joseph Raimondo

Senior lecturer, Division of Cell Biology, Department of Human Biology, Faculty of Health Sciences, UCT & Associate Member of the Institute of Infectious Disease and Molecular Medicine (IDM) and the Neuroscience Institute (NI)

Joseph Raimondo is a neuroscientist who investigates brain function and dysfunction using electrophysiological, optical imaging and computational approaches. His career ambition is to produce outstanding research of both local and global relevance, whilst developing African capacity in cellular neurophysiology and computational neuroscience. The primary aim of his research group is to answer the question: ‘Why do brains seize?’

The lab attempts to answer this question by examining the cellular and circuit level interactions between brain cells, which result in the development of epileptic seizures. They have a focus on how changes to inhibitory synaptic transmission and neuroinflammatory responses relate to the emergence and termination of epileptic seizures.

Key areas of expertise: Neurophysiology , epilepsy, synaptic transmission, plasticity, neurocysticercosis, patch-clamp electrophysiology, optical imaging, neuronal biophysics


Selected publications:

Düsterwald KM, Currin CB, Burman RJ, Akerman CJ, Kay AR, Raimondo JV, 2018, Biophysical models reveal the relative importance of transporter proteins and impermeant anions in chloride homeostasis. eLife, 2018, Sep 27;7. pii: e39575

Raimondo JV, Tomes H, Irkle A, Kay L, Kellaway L, Markram H, Millar RP, Akerman CJ, 2016 Tight Coupling of Astrocyte pH Dynamics to Epileptiform Activity Revealed by Genetically-Encoded pH Sensors. Journal of Neuroscience, 36(26):7002-13

Raimondo, J.V., Burman R.J., Katz, A.A., Akerman C.J. 2015 Ionic dynamics during seizures. Frontiers in Cellular Neuroscience, 9, 419.

Ellender, T.J.*, Raimondo, J.V.*, Irkle, I., Akerman, C.J., 2014 Excitatory effects of parvalbuminexpressing interneurons sustain seizure activity via synchronous after discharges  Journal of Neuroscience, 34(46):15208-22 [*Co-first Author].

Raimondo, J.V., Joyce, B., Kay, L., Schlagheck, T., Newey, S.E., Srinivas, S., Akerman, C.J., 2013 A genetically-encoded chloride and pH sensor for dissociating ion dynamics in the nervous system. Frontiers in Cellular Neuroscience, 7:202

Raimondo, J.V., Kay, L., Ellender, T.J., Akerman, C.J., 2012 Optogenetic silencing strategies differ in their effects on inhibitory synaptic transmission. Nature Neuroscience. doi:10.1038/nn.3143.

Contact details:

Division of Cell Biology
Department of Human Biology
Faculty of Health Sciences, University of Cape Town
Observatory 7925
Republic of South Africa

Email: joseph.raimondo@uct.ac.za

Alternate site: http://raimondolab.org


Group members:


Thijs Verhoog



Hayley Tomes (PhD student)

Christopher Currin (PhD student)

Anja de Lange (PhD student)

Tariro Chatiza (MSc student)

Sasha Tinelli (MSc student)



Christopher Dulla (Tufts University, USA)

Colin Akerman (University of Oxford, UK)

Andrew Trevelyan (Newcastle University, UK)

Henry Markram (École polytechnique fédérale de Lausanne, Switzerland)

Alan Kay (University of Iowa, USA)

Robert Wykes (University College London, UK)

Muazzam Jacobs (Division of Immunology, Department of Pathology, University of Cape Town, RSA)

William Horsnell (Division of Immunology, Department of Pathology, University of Cape Town, RSA)

Graham Fieggen, (Division of Neurosurgery, University of Cape Town)