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Dr. Keren Middelkoop MBChB PhD (UCT) MPH (clinical research)

Desmond Tutu HIV Centre

Keren MiddelkoopSenior Research Officer (Clinical)/ Leader of TB Division, Desmond Tutu HIV Centre (DTHC), Desmond Tutu HIV Foundation, Associate Member of the Institute of Infectious Disease and Molecular Medicine (IDM), Faculty of Health Sciences, University of Cape Town.

Keren Middelkoop has been involved for more than 10 years in a number of DTHC projects including clinical trials for HIV vaccine candidates and antiretroviral treatment options. She has latterly focused on largely public health and epidemiology research, including running a number of community based studies on the HIV epidemic and its impact on community TB. Keren’s work has been recognized internationally. She has received the International Union Against TB and Lung Disease’s Young Investigator of the Year award (2011); and was also winner of the 2014 AU-TWAS (African Union – The World Academy of Sciences) Young Scientist National Award. She is currently pursuing her interests in TB transmission studies and expanding her skills in the field of molecular epidemiology.


Selected publications:

Verkuijl S, Middelkoop K. Protecting our front liners – occupational TB prevention through infection control strategies. Clin Infect Dis. (2016) 62 (Suppl 3):S231-237.

Middelkoop K, Mathema B, Myer L, Shashkina E, Whitelaw A, Kaplan G, Kreiswirth B, Wood R, Bekker LG. Transmission of TB in a high HIV prevalent South African community. J Infect Dis. (2015) Jan 1;211(1):53-61.

Middelkoop K, Bekker LG, Mathema B, Myer L, Shashkina E, Whitelaw A, Kurepina N, Kaplan G, Kreiswirth B, Wood R. Factors impacting Mycobacterium tuberculosis strain success over 10 years in a high TB and HIV burdened South African community. Int J Epidemiol. (2014) Aug;43(4):1114-22.

Kaplan R, Caldwell J, Middelkoop K, Bekker LG, Wood R. The impact of ART on TB case fatality stratified by CD4 count for HIV-positive TB patients in Cape Town, South Africa (2009-2011). J Acquir Immune Defic Syndr. (2014) Aug 15;66(5):487-94.  

Middelkoop K, Bekker LG, Morrow C, Lee N, Wood R. Decreasing household contribution to TB transmission with age: a retrospective geographic analysis of young people in a South African township. BMC Infect Dis. (2014) Apr 23;14(1):221.

Middelkoop K, Rademeyer C, Brown B, Cashmore TJ, Marais JC, Scheibe AP, Bandawe GP, Myer L, Fuchs FD, Williamson C, Bekker LG. Epidemiology of HIV-1 subtypes among men who have sex with men in Cape Town, South Africa. J Acquir Immune Defic Syndr. (2014) Apr 1;65(4):473-80.

Middelkoop K, Bekker LG, Shashkina E, Kreiswirth B, Wood R. Retreatment TB in a South African community: the role of re-infection, HIV and antiretroviral treatment. Int J Tuberc Lung Dis. (2012) Nov;16(11):1510-6.

Wood R, Racow K, Bekker LG, Morrow C, Middelkoop K, Mark D, Lawn SD. Indoor social networks in a South African township: potential contribution of location to tuberculosis transmission. PLoS One. (2012) 7(6):e39246

Middelkoop K, Bekker LG, Liang H, Aquino LDH, Sebastian E, Myer L, Wood R. Force of tuberculosis infection among adolescents in a high HIV and TB prevalence community: a cross-sectional observation study. BMC Infect Dis. (2011) Jun 1;11(1):156.

Middelkoop K, Bekker LG, Myer L, Johnson LF, Kloos M, Morrow C, Wood R. Antiretroviral therapy and TB notification rates in a high HIV prevalence South African community. JAIDS (2011): 56(3): 263-269.


Contact details:

The Desmond Tutu HIV Centre
Wernher & Beit North level 1
Faculty of Health Sciences
University of Cape Town
Observatory 7925
South Africa

Tel:  +27 21 406 6966
Fax: +27 21 406 6255
Email: Keren.Middelkoop@hiv-research.org.za

Alternate site:  www.desmondtutuhivcentre.org.za


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