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Associate Professor Wendy Burgers PhD (Cambridge)

Division of Medical Virology

Wendy Burgers

Associate Professor, Division of Medical Virology, Department of Pathology; Full Member, IDM, Faculty of Health Sciences, UCT; Contributing Investigator, CIDRI-Africa. Current EDCTP Senior Fellow. Former Wellcome Trust Intermediate Fellow in Public Health and Tropical Medicine. 

Wendy Burgers' research group focuses on HIV-TB co-infection. They are studying how HIV affects the immune response to Mycobacterium tuberculosis in HIV-TB co-infected individuals, with a focus on adaptive immunity and in particular, the role of CD4+ Th22 cells in TB immunity. They also study the immunology of HIV pathogenesis, including how immune hyperactivation affects the latent HIV reservoir, and CD4+ Tfh cells in the development of broadly neutralising antibodies.

The work in the laboratory is funded by the European and Developing Countries Clinical Trials Platform (EDCTP), NIH, SA Medical Research Council, National Research Foundation, PRF and NHLS Trust.  

 


Selected publications:

Tanko RF,  Soares AP, Masson L, Werner L, Garrett NJ, Samsunder N, Abdool Karim Q, Abdool Karim SS, Riou C, Burgers WA. (2018). Incomplete normalization of T cell activation and memory subsets following antiretroviral therapy in HIV-infected women. Clinical Immunology, 195:127-138.

Bunjun R, Riou C, Soares AP, Thawer N, Müller TL, Kiravu A, Ginbot Z, Oni T, Goliath R, Kalsdorf B, Von Groote-Bidlingmaier F, Hanekom W, Walzl G, Wilkinson RJ, Burgers WA. (2017) Effect of HIV on the frequency and number of Mycobacterium tuberculosis-specific CD4+ T cells in blood and the airways in latent tuberculosis infection. Journal of Infectious Disease 216:1550-1560.

Tanko RF,  Soares AP, Müller TL , Garrett NJ, Samsunder N, Abdool Karim Q, Abdool Karim SS, Riou C, Burgers WA. (2017) Effect of antiretroviral therapy on the memory and activation profiles of B cells in HIV-infected African women. Journal of Immunology,198:1220-1228.

Riou C, Strickland N, Soares AP, Corleis B, Kwon DS, Wherry EJ, Wilkinson RJ, and Burgers WA. (2016) HIV skews Mycobacterium tuberculosis-specific CD4+ T helper subset diversity. Journal of Immunology, 196:3006-18.

Riou C, Tanko RF, Soares AP, Masson L, Werner L, Garrett NJ, Samsunder N, Abdool Karim Q, Abdool Karim SS and Burgers WA. (2015) Restoration of CD4+ responses to co-pathogens in HIV-infected individuals on antiretroviral therapy is dependent on T cell memory phenotype. Journal of Immunology, 195:2273-81.

 


Contact details:

Room 3.36.1, Level 3, Entrance 4, Falmouth Building
Division of Medical Virology, Department of Pathology
Institute of Infectious Disease and Molecular Medicine
UCT Faculty of Health Sciences, Observatory 7925
South Africa

Tel:  +27 21 406 6090
Fax: +27 21 406 6682
Email: wendy.burgers@uct.ac.za

Alternate site:  www.virology.uct.ac.za/vir/research/hivtb-immunology-pathogenesis-group

 


 Group Members:

Members Position
Kathryn Norman Administrator
Dr Helen Mearns Junior Research Fellow
Dr Marius Tincho Post-doctoral scientist
Dr Jerome Wendoh Milimu Post-doctoral scientist
Rofhiwa Nesamari PhD student
Mohau Steven Makatsa PhD student
Sherazaan Ismail PhD student
Tshepiso Mbangiwa PhD student
Zandile Booi MSc student
Abulele Bekiswa NRF Intern

 


Collaborations:

Carolyn Williamson IDM and Division of Medical Virology, UCT
Anna-Lise Williamson IDM and Division of Medical Virology, UCT
Robert Wilkinson IDM and CIDRI-Africa, UCT
Nigel Garrett CAPRISA, University of KwaZulu-Natal, South Africa
Kogieleum Naidoo CAPRISA, University of KwaZulu-Natal, South Africa
Salim Abdool Karim CAPRISA, University of KwaZulu-Natal, South Africa
Lynn Morris NICD, South Africa
Penny Moore NICD, South Africa
Mario Roederer Vaccine Research Center, USA
Ronald Swanstrom University of North Carolina, USA
Douglas Kwon Ragon Institute, Harvard, USA

 

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