“The Tuberculosis Necrotizing Toxin”
Prof Michael Niederweis
[Host: Prof Valerie Mizrahi]
One of the most prominent features of M. tuberculosis is its unusual outer membrane that plays a crucial role in the intrinsic drug resistance and in survival of M. tuberculosis in vivo. The outer membrane proteins are intriguing because they provide essential functions such as nutrient uptake, have new structures and likely function by novel mechanisms. We discovered the first outer membrane channel protein in mycobacteria, we obtained the first crystal structure of a mycobacterial outer membrane protein, we demonstrated that mycobacteria indeed have two membranes and recently identified two outer membrane proteins of M. tuberculosis. One of those proteins, CpnT, enables secretion of the major exotoxin of M. tuberculosis, a NAD+ glycohydrolase which triggers necroptosis in infected macrophages.
Wolfson Pavilion Lecture Theatre