"Development of low cost recombinant glycoconjugate vaccines for respiratory and enteric diseases"
Professor Brendan Wren
London School of Hygiene and Tropical Medicine
[Host: Prof Keertan Dheda]
|Brendan Wren studied for a PhD in Physical Chemistry and published seminal papers on the effect of ionizing radiation on DNA. He then changed subject discipline and took a Microbiology position at St Bartholomew’s Hospital, London.
In 1999 he moved to the London School of Hygiene and Tropical Medicine (LSHTM) and was awarded a chair in Microbial Pathogenesis. His primary research interest includes the molecular characterization of bacterial virulence determinants and the evolution of virulence. Much research has focused on bacterial glycostructures, including the characterization of lipo-oligosaccharides, capsular polysaccharides and glycosylation systems. He has published over 340 scientific publications and is currently Dean of the Faculty of Infectious and Tropical Diseases at the LSHTM.
This basic research has enabled Wren and colleagues to develop glycoengineering in E. coli. To date, the major application of this technology is the construction of more affordable recombinant glycoconjugate vaccines.
Tue, 13 Nov 2018 -
14:00 to 15:00