Recent Publications

Journal manuscripts

  1. Bahr N, Boulware DR, Marais S, Scriven J, Wilkinson RJ, Meintjes G. Central nervous system immune reconstitution inflammatory syndrome. Current Infectious Disease Reports (2013) 15(6):583-593.
  2. Govender NP, Meintjes G, Bicanic T, Dawood H, Harrison TS, Jarvis JN, Karstaedt AS, Maartens G, McCarthy KM, Rabie H, Variava E, Venter WDF, Boulware DR, Chiller T, Meya DB, Scriven J. Guideline for the prevention, diagnosis and management of cryptococcal meningitis among HIV-infected persons: 2013 update. Southern African Journal of HIV Medicine (2013) 14(2):76-86.
  3. Jarvis JN, Harrison TS, Lawn SD, Meintjes G, Wood R, Cleary S. Cost effectiveness of cryptococcal antigen screening as a strategy to prevent HIV-associated cryptococcal meningitis in South Africa. PLOS ONE (2013) 8(7):e69288.
  4. Kenyon C, Bonorchis K, Corcoran C, Meintjes G, Locketz M, Lehloenya R, Vismer HF, Naicker P, Prozesky H, Wyk M, Bamford C, Du Plooy M, Imrie G, Dlamini S, Borman AM, Colebunders R, Yansouni CP, Mendelson M, Govender NP. A dimorphic fungus causing disseminated infection in South Africa. New England Journal of Medicine (2013) 369(15):1416-1424.
  5. Lai RPJ, Nakiwala JK, Meintjes G, Wilkinson RJ. The immunopathogenesis of the HIV tuberculosis immune reconstitution inflammatory syndrome. European Journal of Immunology (2013) 43(8):1995-2002.
  6. Lawn SD, Meintjes G, McIlleron H, Harries AD, Wood R. Management of HIV-associated tuberculosis in resource-limited settings: a state-of-the-art review. BMC Medicine (2013) 11:253.
  7. Seddon J, Kasprowicz V, Walker NF, Yuen HM, Sunpath H, Tezera L, Meintjes G, Wilkinson RJ, Bishai WR, Friedland JS, Elkington PT. Procollagen iii n-terminal propeptide and desmosine are released by matrix destruction in pulmonary tuberculosis. Journal of Infectious Diseases (2013) 208(10):1571-1578
  8. Tadokera R, Meintjes GA, Wilkinson KA, Skolimowska KH, Walker N, Friedland JS, Maartens G, Elkington PT, Wilkinson RJ. Matrix metalloproteinases and tissue damage in HIV-tuberculosis immune reconstitution inflammatory syndrome. European Journal of Immunology (2013) doi: 10.1002/eji.201343593. [Epub ahead of print]
  9. Jarvis JN, Harrison TS, Lawn SD, Meintjes G, Wood R, Cleary S. Cost Effectiveness of Cryptococcal Antigen Screening as a Strategy to Prevent HIV-Associated Cryptococcal Meningitis in South Africa. PLoS One. 2013 Jul 19;8(7):e69288.
  10. Lehloenya RJ, Shebe K, Hlela C, Dlamini S, Mankahla A, Lapiner V, Meintjes G, Todd G. Aggressive worsening of Sézary syndrome during early antiretroviral therapy. AIDS. 2013 Mar 27;27(6):1035-6.
  11. Lee SS, Meintjes G, Kamarulzaman A, Leung CC. Management of tuberculosis and latent tuberculosis infection in human immunodeficiency virus-infected persons. Respirology. 2013 Aug;18(6):912-22.
  12. Walker NF, Meintjes G, Wilkinson RJ. HIV-1 and the immune response to TB. Future Virol. 2013 Jan;8(1):57-80.
  13. Jarvis JN, Casazza JP, Stone HH, Meintjes G, Lawn SD, Levitz SM, Harrison TS, Koup RA. The phenotype of the Cryptococcus-specific CD4+ memory T-cell response is associated with disease severity and outcome in HIV-associated cryptococcal meningitis. J Infect Dis. 2013 Jun 15;207(12):1817-28.
  14. van der Plas H, Meintjes G, Schutz C, Goliath R, Myer L, Baatjie D, Wilkinson RJ, Maartens G, Mendelson M. Complications of antiretroviral therapy initiation in hospitalised patients with HIV-associated tuberculosis. PLoS One. 2013;8(2):e54145.
  15. Tadokera R, Wilkinson KA, Meintjes GA, Skolimowska KH, Matthews K, Seldon R, Rangaka MX, Maartens G, Wilkinson RJ. Role of the interleukin 10 family of cytokines in patients with immune reconstitution inflammatory syndrome associated with HIV infection and tuberculosis. J Infect Dis. 2013 Apr;207(7):1148-56.
  16. Marais S, Meintjes G, Pepper DJ, Dodd LE, Schutz C, Ismail Z, Wilkinson KA, Wilkinson RJ. Frequency, severity, and prediction of tuberculous meningitis immune reconstitution inflammatory syndrome. Clin Infect Dis. 2013 Feb;56(3):450-60.
  17. Wilkinson KA, Torok ME, Schwander S, Meintjes G. HIV-associated tuberculosis 2012. Clin Dev Immunol. 2012;2012:950964.
  18. Skolimowska KH, Rangaka MX, Meintjes G, Pepper DJ, Seldon R, Matthews K, Wilkinson RJ, Wilkinson KA. Altered ratio of IFN-γ/IL-10 in patients with drug resistant Mycobacterium tuberculosis and HIV- Tuberculosis Immune Reconstitution Inflammatory Syndrome. PLoS One. 2012;7(10):e46481.
  19. Jarvis JN, Govender N, Chiller T, Park BJ, Longley N, Meintjes G, Bekker LG, Wood R, Lawn SD, Harrison TS. Cryptococcal antigen screening and preemptive therapy in patients initiating antiretroviral therapy in resource-limited settings: a proposed algorithm for clinical implementation. J Int Assoc Physicians AIDS Care (Chic). 2012 Nov-Dec;11(6):374-9.
  20. Meintjes G, Boulle A. Immune reconstitution inflammatory syndrome in a large multicenter cohort study: case definition and comparability. Expert Rev Anti Infect Ther. 2012 Jul;10(7):737-41.
  21. Boyles TH, Black J, Meintjes G, Mendelson M. Failure to eradicate Isospora belli diarrhoea despite immune reconstitution in adults with HIV--a case series. PLoS One. 2012;7(8):e42844.
  22. Fatti G, Meintjes G, Shea J, Eley B, Grimwood A. Improved survival and antiretroviral treatment outcomes in adults receiving community-based adherence support: 5-year results from a multicentre cohort study in South Africa. J Acquir Immune Defic Syndr. 2012 Dec 1;61(4):e50-8.
  23. Meintjes G, Scriven J, Marais S. Management of the immune reconstitution inflammatory syndrome. Curr HIV/AIDS Rep. 2012 Sep;9(3):238-50.
  24. Pepper DJ, Marais S, Bhaijee F, Wilkinson RJ, De Azevedo V, Meintjes G. Assessment at antiretroviral clinics during TB treatment reduces loss to follow-up among HIV-infected patients. PLoS One. 2012;7(6):e37634.
  25. Conesa-Botella A, Meintjes G, Coussens AK, van der Plas H, Goliath R, Schutz C, Moreno-Reyes R, Mehta M, Martineau AR, Wilkinson RJ, Colebunders R, Wilkinson KA. Corticosteroid therapy, vitamin D status, and inflammatory cytokine profile in the HIV-tuberculosis immune reconstitution inflammatory syndrome. Clin Infect Dis. 2012 Oct;55(7):1004-11.
  26. Meintjes G, Skolimowska KH, Wilkinson KA, Matthews K, Tadokera R, Conesa-Botella A, Seldon R, Rangaka MX, Rebe K, Pepper DJ, Morroni C, Colebunders R, Maartens G, Wilkinson RJ. Corticosteroid-modulated immune activation in the tuberculosis immune reconstitution inflammatory syndrome. Am J Respir Crit Care Med. 2012 Aug 15;186(4):369-77.
  27. Lawn SD, Harries AD, Meintjes G, Getahun H, Havlir DV, Wood R. Reducing deaths from tuberculosis in antiretroviral treatment programmes in sub-Saharan Africa. AIDS. 2012 Nov 13;26(17):2121-33.
  28. Wilkinson KA, Meintjes G, Seldon R, Goliath R, Wilkinson RJ. Immunological characterisation of an unmasking TB-IRIS case. S Afr Med J. 2012 Mar 2;102(6):512-7.
  29. Schutz C, Ismail Z, Proxenos CJ, Marais S, Burton R, Kenyon C, Maartens G, Wilkinson RJ, Meintjes G. Burden of antituberculosis and antiretroviral drug-induced liver injury at a secondary hospital in South Africa. S Afr Med J. 2012 Mar 2;102(6):506-11.
  30. Kenyon C, Schrueder N, Ntsekhe M, Meintjes G. Heart failure and cardiogenic shock associated with the TB-immune reconstitution inflammatory syndrome. Cardiovasc J Afr. 2012 Apr 12;23(3):e14-7.
  31. Kenyon CR, Fatti G, Schrueder N, Bonorchis K, Meintjes G. The value of blood culture audits at peripheral hospitals. S Afr Med J. 2012 Mar 7;102(4):224-5.
  32. Jarvis JN, Meintjes G, Rebe K, Williams GN, Bicanic T, Williams A, Schutz C, Bekker LG, Wood R, Harrison TS. Adjunctive interferon-γ immunotherapy for the treatment of HIV-associated cryptococcal meningitis: a randomized controlled trial. AIDS. 2012 Jun 1;26(9):1105-13.
  33. Walker NF, Clark SO, Oni T, Andreu N, Tezera L, Singh S, Saraiva L, Pedersen B, Kelly DL, Tree JA, D'Armiento JM, Meintjes G, Mauri FA, Williams A, Wilkinson RJ, Friedland JS, Elkington PT. Doxycycline and HIV infection suppress tuberculosis-induced matrix metalloproteinases. Am J Respir Crit Care Med. 2012 May 1;185(9):989-97.
  34. Govender NP, Chetty V, Roy M, Chiller T, Oladoyinbo S, Maotoe T, Stevens WS, Pinini Z, Spencer D, Venter WD, Jassat W, Cameron D, Meintjes G, Mbengashe T, Pillay Y. Phased implementation of screening for cryptococcal disease in South Africa. S Afr Med J. 2012 Oct 8;102(12):914-7.
  35. Loyse A, Wilson D, Meintjes G, Jarvis JN, Bicanic T, Bishop L, Rebe K, Williams A, Jaffar S, Bekker LG, Wood R, Harrison TS. Comparison of the early fungicidal activity of high-dose fluconazole, voriconazole, and flucytosine as second-line drugs given in combination with amphotericin B for the treatment of HIV-associated cryptococcal meningitis. Clin Infect Dis. 2012 Jan 1;54(1):121-8.

Chapters in books

  1. Meintjes G. HIV-associated Immune Reconstitution Inflammatory Syndrome (IRIS), in: Kumar P, Clark M eds. Kumar & Clark's Clinical Medicine, 8th edition. Saunders Elsevier, 2012: Online Chapter. ISBN: 978-0-7020-4500-4.
  2. Allard D, Meintjes G. HIV and Trauma, in: Oxford Handbook of Trauma, South African edition. Oxford University Press Southern Africa, 2010:374-380. ISBN 978-0-19-598747-8.
  3. French MA, Meintjes G. Disorders of immune reconstitution in patients with HIV infection, in: Infectious Diseases, 3rd Edition. Mosby Elsevier, 2010:975-80. ISBN 978-0-323-04579-7.
  4. Meintjes G. Immune Reconstitution Inflammatory Syndrome, in: Handbook of HIV Medicine, 2nd edition. Oxford University Press Southern Africa, 2009:528-32. ISBN 978-0-19-576135-1.
  5. Meintjes G, Maartens G. Deteriorating tuberculosis in a HIV-infected man despite treatment: immune reconstitution, resistance or drug malabsorption, in: Schaaf HS, Zumla A eds. Tuberculosis. A comprehensive clinical reference. Saunders Elsevier, 2009:852-3. ISBN 978-1-4160-3988-4.
  6. Meintjes GA, Parrish AG. HIV/AIDS, in: Eddleston M, Davidson R, Brent A, Wilkinson R eds. Oxford Handbook of Tropical Medicine, 3rd edition. Oxford University Press, 2008:67-138. ISBN 978-0-19-920409-0.
  7. Soentjens P, Meintjes G, French M, Colebunders R. Immune Reconstitution Inflammatory Syndrome, in: Scheld WM, Hammer SM, Hughes JM eds. Emerging Infections 8. ASM Press, 2008:355-91. ISBN: 978-1-55581-444-1.
  8. Corcoran C, Meintjes G. HIV Virology, in: Temesgen Z, Amoroso A, Gilliam B, Goosby EP, Orenstein R eds. Fundamentals of Global HIV Medicine. IHL Press, 2009:3-11. ISBN: 978-0-9754188-2-6.