Research

My areas of research are the diagnosis, treatment and immunopathogenesis of TB-IRIS, treatment and immunology of cryptococcal meningitis and complications of antiretroviral therapy. Our team conducted a randomised placebo-controlled trial of prednisone for the treatment of TB-IRIS between 2005 and 2008 at GF Jooste Hospital in Cape Town. This was the first clinical trial of treatment for IRIS to be conducted. I am currently site Principal Investigator on the Randomized Controlled Strategy Trial for the Optimal Timing of Antiretroviral Therapy Initiation after Cryptococcal Meningitis (COAT Trial) being conducted in Cape Town and two sites in Uganda.

 

Funding

  1. Wellcome Trust Intermediate Fellowship in Public Health and Tropical Medicine. Awarded: 2013-2017.  Title: "Defining interventions to reduce mortality in severe HIV-associated TB". Role: Personal fellowship.
  2. European and Developing Countries Clinical Trials Partnership (EDCTP) Strategic Primer Award. Awarded 2012-2014. Title: "Preventing tuberculosis-associated immune reconstitution inflammatory syndrome in high-risk patients: a randomised placebo-controlled trial of prednisone". Role: Main applicant and PI. This award receives co-funding from the South African Department of Science and Technology.
  3. The National Institute of Allergy and Infectious Diseases (US). "Phase IV, Randomized Controlled Strategy Trial for the Optimal Timing of Antiretroviral Therapy Initiation after Cryptococcal Meningitis." Awarded: 2010-5. Role: Site Principal Investigator. The Protocol Chair is Dr David Boulware (University of Minnesota, US)). 
  4. National Research Foundation rating funding awarded in 2013 for 6 years (B2 rating).

 

Pred-ART Clinical Trial group

SITE INITIATION AND TRAINING WEEK FOR THE EDCTP-FUNDED Pred-ART CLINICAL TRIAL (29 July-2 Aug 2013)

Lut Lynen (ITM, Antwerp), Liz Blumenthal (UCT), Alison Swartz (UCT), Yoilsa Sigila (UCT), Christiana Noestlinger (ITM), Amy Nair (UCT), Raffaella Ravinetto (ITM), Monica Magwayi (UCT), Charlotte Schutz (UCT), Holly Gathercole (research elective student) and Graeme Meintjes. Details of the trial can be found at: http://clinicaltrials.gov/ct2/show/NCT01924286