Dr. Catherine Riou PhD (Lyon)
Division of Medical Virology
Senior Research Officer, Division of Virology, Department of Pathology
Associate Member, Institute of Infectious Disease and Molecular Medicine (IDM), Faculty of Health Sciences, University of Cape Town
Current research interests include the impact of HIV infection and antiretroviral therapy (ART) on T cell responses to co-pathogens (such as Mycobacterium tuberculosis) with a particular focus on the transcriptional regulation of immune responses.
KEY EXPERTISE: T cell immunology, Infectious Diseases, HIV/TB co-infection.
Riou C, Tanko RF, Soares AP, Masson L, Werner L, Garrett NJ, Samsunder N, Abdool Karim Q, Abdool Karim SS and Burgers WA. Restoration of CD4+ responses to co-pathogens in HIV-infected individuals on antiretroviral therapy is dependent on T cell memory phenotype. J Immunol. (2015) 195:2273-81.
Riou C, Burgers WA, Mlisana K, Koup RA, Roederer M, Abdool Karim SS, Carolyn Williamson C, Gray CM. Differential impact of magnitude, polyfunctional capacity and specificity of HIV-specific CD8+ T cell responses on HIV viral set point. J Virol. (2014) 88:1819-1824.
Riou C, Treurnicht F, Abrahams M, Mlisana K, Liu M, Goonetilleke N, Koup R, Roederer M, Abdool Karim S, de Bruyn G, Williamson C, Gray CM, Burgers W; CAPRISA 002 Study Team. Increased memory differentiation is associated with decreased polyfunctionality for HIV but not for CMV-specific CD8+ T cells. J Immunol. (2012) 189:3838-47.
Burgers WA*, Riou C*, Mlotshwa M, Maenetje P, de Assis Rosa D, Brenchley J, Mlisana K, Douek DC, Koup R, Roederer M, de Bruyn G, Karim SA, Williamson C, Gray CM; CAPRISA 002 Acute Infection Study Team. Association of HIV-specific and total CD8+ T memory phenotypes in subtype C HIV-1 infection with viral set point. J Immunol. (2009) 182(8):4751-61.
Van Grevenynghe J, Procopio F, He Z, Chomont N, Riou C, Zhang Y, Gimmig S, Boucher G, Wilkinson P, Shi Y, Yassine-Diab B, Said E, Trautmann L, El-Far M, Balderas R, Boulassel M, Routy JP, Haddad E, Sekaly RP. Transcriptional factor Foxo3a controls the persistence of memory CD4+T cells in HIV infection. Nature Medicine (2008) 14:266-274.
Riou C, Yassine-Diab B, Van Grevenynghe J, Somogyi R, Greller L, Gagnon D, Gimmig S, Wilkinson P, Shi Y, Cameron M, Campos-Gonzalez R, Balderas R, Kelvin D, Sekaly RP and Haddad E. Convergence of TCR and cytokines signaling leads to FOXO3a phosphorylation and drives the survival of Central Memory CD4+ T cells. J Exp Med. (2007) 204:79-9.
Room 3.36.2, Falmouth Building
Faculty of Health Sciences
University of Cape Town
Tel: +27 21 650 5393
Alternate site: www.virology.uct.ac.za
Dr Natalie Strikland, Postdoctoral fellow (co-host)
Ramla Tanko, PhD student (co-supervision)