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Associate Members

Dr. J. Claire Hoving  BSc Hons MSc(Med) PhD (UCT)

Claire Hoving

Lecturer, NRF Research Career Advancement Fellow, Division of Immunology, Department of Pathology

Associate Member of the Institute of Infectious Disease and Molecular Medicine (IDM), Faculty of Health Sciences, UCT

Claire Hoving is a basic immunologist and her research aims at understanding host immune responses to disease with a particular focus on HIV-related fungal infections and Mycobacterium tuberculosis. Fungal infections are often an overlooked clinical and public health issue. Pneumocystis jirovecii is an opportunistic fungal pathogen of immunocompromised hosts and is a common cause of pneumonia and death in patients with HIV/AIDS. There are very few researchers dissecting the mechanisms of fungal infections in Africa, yet research in this field will provide new insights into protective immunity and may lead to improved treatments for immunocompromised hosts. Claire is appointed as an NRF Research Career Advancement fellow and is an NRF Y-rated researcher.

 


Selected publications:

Hoving JC, Nieuwenhuizen NE, Schäfer G, Katz A, Brombacher F. IL-13 signals independent of IL-4 receptor-alpha chain to drive ovalbumin-induced dermatitis. J Invest Dermatol. (2016)  Feb 16.

Wilson* GJ, Marakalala* MJ, Hoving JC*, van Laarhoven A*, Drummond RA, Kerscher B, Keeton R, van de Vosse E, Ottenhoff TH, Plantinga TS, Alisjahbana B, Govender D, Besra GS, Netea MG, Reid DM, Willment JA, Jacobs M, Yamasaki S, van Crevel R, Brown GD. The C-type lectin receptor CLECSF8/CLEC4D is a key component of anti-mycobacterial immunity. Cell Host Microbe (2015) 17:252-259.

Hoving JC, Wilson GJ and Brown GD. Signalling C-type lectin receptors, microbial recognition and immunity. Cell Microbiol. (2014) 16;185-194. (review)

Hoving JC, Kirstein F, Nieuwenhuizen NE, Fick LC, Hobeika E, Reth M, Brombacher F. Immunoglobulin E-producing B lymphocytes mediate colitis in BALB/c mice. Gastroenterology (2012) Jan; 142(1): 96.


Contact details:

Room S1.10 Wernher & Beit South
Institute of Infectious Disease and Molecular Medicine
Faculty of Health Sciences
University of Cape Town
Observatory 7925
South Africa

Tel:  +27 21 406 6035
Fax: +27 21 406 6029

email:  Jennifer.Hoving@uct.ac.za


Group members:

Patricia Otieno (PhD Student)

Dr Roanne Keeton (Research Officer)


Collaborations:

Gordon Brown (MRC Centre for Medical Mycology, Aberdeen fungal group, University of Aberdeen, UK)

Jay Kolls (Professor of Paediatrics and Immunology, University of Pittsburgh School of Medicine, USA)

Bernhard Ryffel (Director of Research, CNRS, and University Orléans, France)

Georgia Schäffer (Medical Biochemistry, UCT)

Catherine Kaschula (Department of Chemistry, UCT)

Muazzam Jacobs (Experimental Tuberculosis and Immunology Research Group, UCT)

Frank Brombacher (Cytokines and disease group, UCT)