Professor Clive Gray MSc PhD(WITS)
HIV Immunology Group
Chair and Head of Division of Immunology, Department of Pathology, & Member, Institute of Infectious Disease and Molecular Medicine (IDM), Faculty of Health Sciences, UCT; Visiting Professor, South African National Bioinformatics Institute, University of the Western Cape; Visiting Professor, Department of Immunology, Duke University, North Carolina, USA
Clive Gray has published numerous papers on identifying T cell responses to HIV in early and acute infection. His particular interest lies in understanding the immunopathogenesis of HIV and what constitutes survival and differentiation of antigen-specific memory CD4 and CD8 T cells, and what would be required with vaccine-induced immunity.
During his postdoctoral fellowship at the Center for AIDS Research, Stanford University, USA, Clive was one of the first to do research on the restoration of immunity in HIV-infected individuals receiving highly active antiretroviral therapy and then to examine the specific nature of T cells using MHC tetramers. He returned to South Africa in 1998 and built up an internationally recognised immunology laboratory at the National Institute for Communicable Diseases, Johannesburg. Clive played a formative role in the South African AIDS Vaccine Initiative (SAAVI) and has been part of the SAAVI development team for the DNA and MVA candidate vaccines that have now completed clinical trials in the USA and South Africa. He was the Principal Investigator for the HIV Vaccine Trials Network (HVTN) immunology laboratory in Southern Africa, where he was responsible for measuring vaccine immunogenicity in clinical trials in the region.
In 2004, he received the International Leadership Award from the Elizabeth Glaser Pediatric AIDS Foundation for developing Immunopaedia, an on-line learning website to simplify immunology for paediatricians and clinicians in general (www.immunopaedia.org.za).
Projects in the HIV Immunology Group focus on different properties of T cells, the epitopic regions that are recognized during early infection, how they contribute to homeostatic balance and ultimately how this balance is disrupted upon HIV exposure and infection. The projects are highly collaborative within the IDM/UCT and across multiple international groups and the overall focus is on defining biological risk factors for HIV acquisition.
Ferrian S, Manca C, Lubbe S, Conradie F, Ismail N, Kaplan G, Gray CM, Fallows DA. Combination of baseline plasma immune markers can predict therapeutic response in multidrug resistant tuberculosis. PLoS ONE (2017) 12 (5):e0176660.
Coetzee B, Tomlinson M, Osawe S, Amibiku A, Kagee A, Rosenthal KL, Abimiku A, Gray CM, Cameron DW, Ball TB, Jaspan H, Burgener A, Blackburn J, Kagee A, Tomlinson M, Singer J, Kiravu A, Osawe S, Datong P. Barriers to and facilitators of adherence to exclusive breastfeeding practices among HIV infected and non-infected women in Jos, Nigeria. Maternal and Child Health Journal (2017) 21(4):953-960.
Chege GK, Burgers WA, Müller TL, Gray CM, Shephard EG, Barnett SW, Ferrari G, Montefiori D, Williamson C, Williamson AL. DNA-MVA-protein vaccination of rhesus macaques induces HIV-specific immunity in mucosal-associated lymph nodes and functional antibodies. Vaccine (2017) 35(6):929-937.
Sharma S, Aralaguppe SG, Abrahams MR, Williamson C, Gray C, Balakrishnan P, Saravanan S, Murugavel KG, Solomon S, Ranga U. The PTAP sequence duplication in HIV-1 subtype C Gag p6 in drug-naive subjects of India and South Africa. BMC Infectious Diseases (2017) 17(1):95.
Chopera DR, Ntale R, Ndabambi N, Garrett N, Gray CM, Matten D, Karim QA, Karim SA, Williamson C. Early evolution of human leucocyte antigen-Associated escape mutations in variable Gag proteins predicts CD4R decline in HIV-1 subtype C-infected women. AIDS (2017) 31(2):191-197.
Division of Immunology
Department of Pathology
Institute of Infectious Disease and Molecular Medicine
UCT Faculty of Health Sciences
Anzio Road, Observatory 7925
Tel: +27 21 406 6356
Fax: +27 21 406 6029
|Guido Ferrari, Barton Haynes, Marcella Sarzotti-Kelsoe||Duke University, Durham NC|
|Julie McElrath, Steve de Rosa, Helen Horton||University of Washington, Seattle|
Cathal Seoighe, Anna-Lise Williamson
|University of Cape Town|
|Win Hide||University of the Western Cape|
|Rick Koup||Vaccine Research Center, NIH|
|Mike Betts||University of Pennsylvania|
|Guy de Bruyn, Glenda Gray||University of the Witwatersrand: Perinatal HIV Research Unit|
|Gavin Churchyard||Aurum Health Institute|
|Salim Abdool Karim||University of KwaZulu-Natal|
|Tammy Meyers||Harriet Shezi Clinic, Soweto|
|Gayle Sherman||Coronation Hospital, Johannesburg|
|Markus Maeurer||Karolinska Institute, Sweden|
|Rafick Sekaly||University of Montreal|