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Professor Edward D Sturrock PhD (Cape Town) FRSSAf Fellow of UCT

Zinc Metalloprotease Research Group

Ed Sturrock

Prof and Head of Department of Integrative Biomedical Sciences, University of Cape Town;
Fellow of Royal Society of South Africa; Fellow of UCT; Member of ASSAf.

Main areas of research/expertise:
Protein biochemistry, protease inhibitor design, enzyme structure-function relationships, ectodomain shedding of angiotensin-converting enzyme.

Biosketch
PhD, 1994, on the synthesis and metabolism of bilirubin. Went on to do a postdoctoral fellowship at Harvard Medical School where he started his research on angiotensin-converting enzyme (ACE), a protein that plays a key role in blood pressure regulation. In 2003 he was awarded a Wellcome Trust International Senior Research Fellowship for his work on ACE. His research interests include: structure-function aspects of ACE; design and synthesis of novel domain-selective ACE inhibitors; and the processing of the membrane-anchored proteins. He has published over 110 peer-reviewed papers and 5 patents, and has trained more than 35 students at PhD and MSc levels. He currently holds a NRF B1 rating. Together with colleagues in the US and UK, he founded a spin-off company AngioDesign Ltd. 

 


Selected recent publications:

Cozier GE, Schwager SL, Sharma RK, Chibale K, Sturrock ED, Acharya KR (2018). Crystal structures of sampatrilat and sampatrilat-Asp in complex with human ACE - a molecular basis for domain selectivity. FEBS J. 285(8):1477-1490.

Abrie JA, Moolman WJA, Cozier GE, Schwager SL, Acharya KR, Sturrock ED (2018). Investigation into the mechanism of homo- and heterodimerization of Angiotensin-Converting Enzyme. Mol Pharmacol. 93(4):344-354.

Fienberg S, Cozier GE, Acharya KR, Chibale K, Sturrock ED (2018). The Design and Development of a Potent and Selective Novel Diprolyl Derivative That Binds to the N-Domain of Angiotensin-I Converting Enzyme.  J Med Chem. 11;61(1):344-359.

Ramasamy V, Mayosi BM, Sturrock ED, Ntsekhe M. (2018) Established and novel pathophysiological mechanisms of pericardial injury and constrictive pericarditis. World J Cardiol. 10(9):87-96, Review.

Sharma, R.K., Espinoza-Moraga, M., Poblete, H., Douglas, R.G., Sturrock, E.D., Caballero, J., Chibale, K. The Dynamic Nonprime Binding of Sampatrilat to the C-Domain of Angiotensin-Converting Enzyme. Journal of Chemical Information and Modeling (2016) 56(12):2486-2494

Conrad, N., Schwager, S.L.U., Carmona, A.K., Sturrock, E.D. The effect of structural motifs on the ectodomain shedding of human angiotensin-converting enzyme. Biochemical and Biophysical Research Communications (2016) 481,02-Jan,111-116

Lubbe, L., Sewell, B.T., Sturrock, E.D. The influence of angiotensin converting enzyme mutations on the kinetics and dynamics of N-domain selective inhibition. FEBS Journal (2016) 283(21):3941-3961

Larmuth, K.M., Masuyer, G., Douglas, R.G., Schwager, S.L., Acharya, K.R., Sturrock, E.D. Kinetic and structural characterization of amyloid-β peptide hydrolysis by human angiotensin-1-converting enzyme. FEBS Journal (2016) 283(6):1060-1076

 


Contact details:

Wernher and Beit North Building Level 3
Faculty of Health Sciences
University of Cape Town
Observatory 7925
South Africa

Tel:  +27 21 406 6312
Fax: +27 21 406 6470

email: edward.sturrock@uct.ac.za

Alternate site:

http://www.health.uct.ac.za/fhs/departments/IBMS

http://www.chemsysbio.uct.ac.za/sturrock-group

 


Group members:

 

GROUP MEMBERS Position
Sylva Schwager Chief Scientific Officer
Afolake Arowolo Post Doctoral Fellow
Lizelle Lubbe Post Doctoral Fellow
Vinasha Ramasamy PhD Student
Palesa Seele PhD Student
Lindile Bleki Departmental Lab Assistant

 


Collaborations:

Name Institution
Kelly Chibale Chemistry, UCT
Mpiko Ntsekhe Medicine, UCT
Trevor Sewell Electron Microscope Unit, Molecular and Cell Biology, UCT
Kevin Naidoo Chemisty, UCT
Ravi Acharya University of Bath, UK
Sergei Danilov University of Illinois at Chicago, USA
Adriana Carmona Universidade Federal de São Paulo, Brazil
Rhian Touyz University of Glasgow, UK
Cowan JA The Ohio State University, USA
Poglitsch Marco Attoquant Diagnostics GmbH, Vienna , Austria
Mario Ehlers Immune Tolerance Network, University of California, San Francisco, USA
Martinez J Université de Montpellier, Montpellier, France