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Professor Mark Nicol MBBCh MMed(Wits) DTM&H FCPath(Microbiol) SA PhD(Cape Town)

Selected publications  |  Contact details  |  Group members  |  Collaborations

Mark Nicol

Wernher and Beit Professor of Medical Microbiology; Head, Division of Medical Microbiology and Member of the Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, UC; National Health Laboratory Service.

I am a clinical microbiologist with a particular interest in tuberculosis and in developing and testing point of care diagnostics suitable for the developing world. My joint position with the University of Cape Town and the National Health Laboratory Service of South Africa affords me the opportunity to coordinate the activities of a research group involved in a range of clinical and laboratory based studies with a clinical and laboratory team involved directly in patient diagnosis and care. This interface between research and diagnostic laboratories is a major strength of the Division and provides an excellent platform for clinical laboratory research relevant to the developing world.

KEY EXPERTISE: Novel diagnostics for tuberculosis, strain biology of tuberculosis


Latest publications:

Rockwood N., Wojno J., Ghebrekristos Y., Nicol M.P., Meintjes G., Wilkinson R.J. Utility of second-generation line probe assay (Hain MTBDRplus) directly on 2-month sputum specimens for monitoring tuberculosis treatment response. Journal of Clinical Microbiology (2017) 55(5):1508-1515

Wilmore S.M.S., Kranzer K., Williams A., Makamure B., Nhidza A.F., Mayini J., Bandason T., Metcalfe J., Nicol M.P., Balakrishnan I., Ellington M.J., Woodford N., Hopkins S., McHugh T.D., Ferrand R.A. Carriage of extended-spectrum beta-lactamase-producing enterobacteriaceae in HIV-infected children in Zimbabwe. Journal of Medical Microbiology (2017) 66(5),474:609-615

Whittaker E., Nicol M., Zar H.J., Kampmann B. Regulatory T cells and pro-inflammatory responses predominate in children with tuberculosis. Frontiers in Immunology (2017) 8 APR, 448

Fisher M., Dolby T., Surtie S., Omar G., Hapeela N., Basu D., DeWalt A., Kelso D., Nicol M., McFall S. Improved method for collection of sputum for tuberculosis testing to ensure adequate sample volumes for molecular diagnostic testing. Journal of Microbiological Methods (2017) 135:35-40

Lawn S.D., Kerkhoff A.D., Burton R., Schutz C., Boulle A., Vogt M., Gupta-Wright A., Nicol M.P., Meintjes G. Diagnostic accuracy, incremental yield and prognostic value of Determine TB-LAM for routine diagnostic testing for tuberculosis in HIV-infected patients requiring acute hospital admission in South Africa: A prospective cohort. BMC Medicine (2017) 15(1):67

Khumalo J., Nicol M., Hardie D., Muloiwa R., Mteshana P., Bamford C. Diagnostic accuracy of two multiplex real-Time polymerase chain reaction assays for the diagnosis of meningitis in children in a resource-limited setting. PLoS ONE (2017) 12(3): e0173948

Cox H., Dickson-Hall L., Ndjeka N., van’t Hoog A., Grant A., Cobelens F., Stevens W., Nicol M. Delays and loss to follow-up before treatment of drug-resistant tuberculosis following implementation of Xpert MTB/RIF in South Africa: A retrospective cohort study. PLoS Medicine (2017) 14(2):e1002238


Contact details:

5th Floor, Falmouth Building
Division of Medical Microbiology
Anzio Road, Faculty of Health Sciences
Observatory 7925
South Africa

Tel:  +27 21 406 6083
Fax: +27 21 448 8153 


Alternate site: 


Group members:

Dr Widaad Zemanay Postdoctoral fellow
Dr Mamadou Kaba Wellcome Trust Research Fellow
Dr Lemese Ah Tow Edries Scientific officer
Dr Eliya Madikane Medical scientist
Dr Andrew Whitelaw Principal pathologist
Dr Colleen Bamford Senior Pathologist
Dr Mischka Moodley Pathologist
Dr Neisha Mohess Medical Officer
Dr Welile Sikhondze Medical Officer



National Institutes of Health, Tuberculosis Clinical Diagnostic Research Consortium

Tuberculosis Unit, Johns Hopkins University

Division of Infectious Diseases, Boston University

Department of Medicine, Imperial College

Center for Point-of-Care Diagnostics for Global Health (GHDx Center), Northwestern University

Department of Paediatrics, Melbourne Children's Hospital

J. Craig Venter Institute, Rockville

Foundation for Innovative New Diagnostics, Geneva

Aurum Institute, Johannesburg

Next Dimension Technologies, Pasadena