Professor Valerie Mizrahi PhD(UCT) OMS MASSAf FRSSAf FAAM Fellow of UCT
MRC/NHLS/UCT Molecular Mycobacteriology Research Unit
DST/NRF Centre of Excellence for Biomedical TB Research
Director and Full Member, Institute of Infectious Disease and Molecular Medicine; Director, MRC/NHLS/UCT Molecular Mycobacteriology Research Unit (MMRU) which constitutes the UCT node of the DST/NRF Centre of Excellence for Biomedical TB Research (CBTBR); Division of Medical Microbiology, Department of Pathology, Faculty of Health Sciences, University of Cape Town; Senior International Research Scholar, Howard Hughes Medical Institute, USA, until 2017.
Received the L'Oréal-UNESCO Award for Women in Science (2000); the Gold Medal from the South African Society for Biochemistry and Molecular Biology for her contributions to the field (2006); the Department of Science and Technology's Distinguished Woman Scientist Award (2006); named to the Order of Mapungubwe (2007); and awarded the Institut de France's Christophe Mérieux Prize for her work in tuberculosis research (2013).
Research in the MMRU is focused on aspects of mycobacterial physiology and metabolism that are of relevance to tuberculosis drug discovery, drug resistance, mycobacterial persistence and tuberculosis transmission. Currently, the Unit is actively involved in studying mechanisms of DNA metabolism, nucleotide metabolism, and cofactor metabolism in Mycobacterium tuberculosis.
As a Unit that receives funding through two major grants from the South African government, research capacity development forms a key focus of the MMRU’s work.
The MMRU comprises senior scientists, post-doctoral fellows, and PhD and MSc students, and also participates in several major TB drug discovery consortia funded by grants from the Bill & Melinda Gates Foundation under the TB Drug Accelerator program (HIT-TB), the Seventh Framework Programme of the European Union (MM4TB), and the SHIP programme of the SAMRC.
Warner, D.F., Ndwandwe, D.E., Abrahams, G.L., Kana, B.D., Venclovas, Č., and Mizrahi, V. 2010. Essential roles for imuA’ and imuB-encoded accessory factors in DnaE2-dependent mutagenesis in mycobacteria. Proc. Natl. Acad. Sci. USA 107:13093-13098.
Abrahams, G.L., Kumar, A., Savvi, S., Hung, A.W., Wen, S., Abell, C.A., Barry, C.E. III, Sherman, D.R., Boshoff, H.I.M, and Mizrahi, V. 2012. Pathway-selective sensitization of Mycobacterium tuberculosis for target-based whole-cell screening. Chemistry & Biology 19:844-854.
Warner D.F., Evans, J.C., and Mizrahi, V. 2014. Nucleotide metabolism and DNA replication. In: Molecular Genetics of the Mycobacteria, 2nd Edition (Hatfull, G.F. & Jacobs, W.R., Jr., eds). ASM Press, Washington, ch. 30, pg. 635-656. doi: 10.1128/microbiolspec.MGM2-001-2013
Warner, D.F. and Mizrahi, V. 2014. Translation of genomics research into control of tuberculosis: lessons learned and future prospects. Genome Biol. 15:514. doi:10.1186/s13059-014-0514-z
Warner, D.F., Koch, A., and Mizrahi, V. 2015. Diversity and disease pathogenesis in Mycobacterium tuberculosis. Trends Microbiol. 23:14-21. doi: 10.1016/j.tim.2014.10.005.
Singh, V., Brecik, M., Mukherjee, R., Evans, J.C., Svetlíková, S., Blaško, J., Blackburn, J., Warner, D.F., Mikušová, K. and Mizrahi, V. 2015. The complex mechanism of antimycobacterial action of 5-fluorouracil. Chem. Biol. 22:1-13.
Evans JC, Trujillo C, Wang Z, Eoh H, Ehrt S, Schnappinger D, Boshoff HIM, Rhee KY, Barry CE, Mizrahi V. 2016. Validation of CoaBC as a bactericidal target in the coenzyme a pathway of Mycobacterium tuberculosis. ACS Infectious Diseases 2(12):958-968.
Singh V, Mizrahi V. Identification and validation of novel drug targets in Mycobacterium tuberculosis. 2016. Drug Discovery Today 22(3):503-509.
Room 3.01, Wolfson Pavilion
UCT Faculty of Health Sciences
Cape Town, South Africa
Tel: +27 21 4066098
Fax: +27 21 4066068
|A/Professor Digby Warner|
|Dr Joanna Evans||Junior Research Fellow|
|Miss Audrey Jordaan||Lab Technologist|
|Mrs Ronnett Seldon||H3-D Screening Technician|
|Miss Lameeza Jakoet||Administrative Assistant|
|Dr Pooja Agarwal||Postdoctoral fellow|
|Dr Mandy Mason||Postdoctoral fellow|
|Mr Ryan Dinkele||PhD (Medical Microbiology)|
|Ms Irene Gobe||PhD (Medical Microbiology)|
|Mr Terry Kipkorir||PhD (Medical Microbiology)|
|Ms Zela Martin||PhD (Medical Microbiology)|
|Mr Rendani Mbau||PhD (Medical Microbiology)|
|Mr Michael Reiche||PhD (Medical Microbiology)|
|Ms Sophia van Coller||PhD (Medical Microbiology)|
Dr. Clifton E. Barry III, NIAID, NIH, USA
Dr. Helena I. Boshoff, NIAID, NIH, USA
Prof. Paul Wyatt & Dr. Simon Green, Drug Discovery Unit, University of Dundee
Prof. Menico Rizzi, Università degli Studi del Piemonte Orientale, Italy
Dr. Janos Pato, Vichem, Hungary
Prof. Chris Abell, Cambridge University, UK
Prof. Tom Blundell, Cambridge University, UK
Dr. David Ascher, Cambridge University
Prof. Lizbeth Hedstrom, Brandeis University
Prof Kyu Rhee, Cornell University
Prof Erick Strauss, Stellenbosch University
Emer. Prof. Siamon Gordon, University of Oxford
Dr. Fernando Martinez Estrada, University of Surrey
Prof. Rolf Müller, Helmholtz Institute for Pharmaceutical Research, Saarland
Dr. David Olsen & Katherine Young, Merck Research Laboratories, USA
Prof. Deborah Hung, Broad Institute of MIT & Harvard