Selected Recent Publications

Bridget C, Soares NC, Elise de Kock & Blackburn JM. (under revision) Mycobacterial proteomics: analysis of expressed proteome and post-translational modification to identify candidate virulence factors. Expert Rev Proteomics.

Young BL, Mlamla Z, Gqamana P, Smit S, Roberts T, Peter J, Theron G, Govender U, Dheda K & Blackburn JM (2014) The Identification of Mycobacterium Tuberculosis-specific Biomarkers in Human Urine Samples From Patients with Active Tuberculosis. European Respiratory Journal 43, 1719–1729.

Beeton-Kempen N, Duarte J, Shoko A, Serufuri J-M, John T, Cebon J & Blackburn JM (2014) Quantitative determination of autoimmune profiles using a novel cancer-testis antigen microarray platform. International Journal of Cancer 135, 1842–1851.

Singh V, Brecik M, Mukherjee R, Evans JC, Svetlíková Z, Blackburn J, Warner DF, Mikušová K & Mizrahi V (2014) The Complex Mechanism of Antimycobacterial Action of 5-Fluorouracil. Chemistry & Biology. In the press.

Paruk F, Blackburn JM, Friedman IB & Mayosi BM (2014) National expenditure on health research in South Africa: What is the benchmark? S. Afr. Med. J. 104, 468-474.

Blackburn JM, Young-Gqamana & Dheda K (2014) Mycobacterium tuberculosis-specific biomarkers for diagnosing tuberculosis in a urine sample PCT application no. IB2014/063987.

Soares NC, Spat P, Mendez JA, Nakedi K, Aranda J, Bou G. (2014) Ser/Thr/Tyr phosphoproteome characterization of Acinetobacter baumannii: comparison between a reference strain and a highly invasive multidrug-resistant clinical isolate. J Proteomics. May 6;102:113-24.

Adeola H, Goosen RW, Goldberg P & Blackburn J (2014) Prospects of 'Omics Based Molecular Approaches in Colorectal Cancer Diagnosis & Treatment in the Developing World: A Case Study in Cape Town, South Africa. Chapter 15, pp363- 401. In Colorectal Cancer - Surgery, Diagnostics and Treatment (Ed. Khan J). InTech, Rijeka, Croatia. ISBN 980-953-307-958-0.

Arendse L, Blundell T & Blackburn J (2013) Combining in silico protein stability calculations with structure-function relationships to explore the effect of polymorphic variation on cytochrome P450 drug metabolism. Current Drug Metabolism 14, 745-763.

Soares NC, Spat P, Krug K & Macek B. (2013) Global dynamics of Escherichia coli proteome and phosphoproteome during growth in minimal medium. J Proteome Res. Jun 7;12(6):2611-21.

Viljoen KS & Blackburn JM (2013) Quality assessment and data handling methods for Affymetrix Gene 1.0 ST arrays with variable RNA integrity. BMC Genomics 14, 14.

Muth T, Peters J, Blackburn J, Rapp E & Martens L (2013) ProteoCloud: a full-featured open source proteomics cloud computing pipeline. J. Proteomics. http://dx.doi.org/10.1016/j.jprot.2012.12.026.

Mendez JA, Soares NC, Mateos J, Gayoso C, Rumbo C, Aranda J, Tomas M & Bou G (2012) Extracellular proteome of highly invasive multidrug-resistant clinical strain of Acinetobacter baumannii. J Proteome Res Dec 7;11(12):5678-94. (#) Both author contributed equally to this work.

Soufi B, Soares NC, Ravickumar V, Macek B (2012) Proteomics reveals evidence of cross-talk between protein modifications in bacteria: focus on acetylation and phosphorylation. Curr Opin Microbiol. Jun;15(3):357-63. (#) Both author contributed equally to this work.

Duarte J, Serufuri J-M, Mulder N & Blackburn J (2012) Protein Function Microarrays: Design, Use and Bioinformatic Analysis in Cancer Biomarker Discovery and Quantitation. In Bioinformatics of Human Proteomics: Translational Bioinformatics (Wang X, ed). Springer, NY. ISBN 978-94-007-5811-7.

Ramautar A, Mabandla M, Blackburn J & Daniels WMU (2012) Inhibition of HIV-1 tat-induced transactivation and apoptosis by the divalent metal chelators, fusaric acid and picolinic acid - Implications for HIV-1 dementia. Neuroscience Research 74, 59-63.

Mayosi BM, Mekwa NJ, Blackburn J, Coovadia H, Friedman IB, Jeenah M, Madela-Mntla EN, Magwaza AS, Makatini Z, Mkize DL, Mokgatle-Makwakwa C, Mokwena K, Nevhutalu K & Paruk F (2011) Strengthening research for health, innovation and development in South Africa. Department of Health, South Africa. http://www.nhrc.org.za.

Zawaira A, Coulson L, Gallotta M, Karimanzira O & Blackburn J (2011) On the deduction and analysis of singlet and two-state gating-models from the static structures of mammalian CYP450. J. Struct. Biol. 282-293.

Zawaira A, Ching LY, Coulson L, Blackburn J & Yap CW (2011) An expanded, unified Substrate Recognition Site map for mammalian Cytochrome P450s: analysis of molecular interactions between 15 mammalian CYP450 isoforms and 868 substrates. Current Drug Metabolism 12, 684-700.

Otto DME, Campanero-Rhodes MA, Karamanska R, Powell AK, Bovin N, Turnbull JE, Field R, Blackburn J, Feizi T & Crocker PR (2011) A versatile expression system for genome-wide screening of secreted and type 1 membrane proteins for glycan and protein interactions. Anal. Biochem. 411, 261-270.

Blackburn JM, Shoko A & Beeton-Kempen N (2011) Miniaturised, microarray-based assays for chemical proteomic studies of protein function. In Chemical Genomics: Reviews and Protocols (Zanders E, ed) The Humana Press, Springer, NY. ISBN 978-1-61779-348-6.

Blackburn JM & Shoko A (2011) Protein function microarrays for systems-oriented proteomic analysis. In Protein Microarrays: Methods in Molecular Biology (Korf U, Ed). The Humana Press, Springer, NY. ISBN 978-1-61779-285-4.

Blackburn JM & Beeton-Kempen N (2010) A cytochrome P450 Biochip. RSA patent application no 2010/08127.

Blackburn JM, Krishnan S & Evans M (2010) A method of determining the identity and amount of an analyte molecule present in a complex sample.  RSA patent application no 2010/05520.

Dheda K, Lenders L, Davids V, Roberts T, Meldau R, Ling D, Brunet L, van Zyl Smit R, Peters J, Badri M , Sechi L, Sharma S, Hoelscher M, Dawson R, Whitelaw A, Blackburn J, Pai M & Zumla A (2010) Clinical utility of a commercial LAM-ELISA assay for TB diagnosis in HIV-infected patients using urine and sputum samples. Plos One, 5, e9848 (pp1-8).

Zawaira A, Gallotta M, Beeton-Kempen N, Coulson L, Marais P, Kuttel M & Blackburn J (2010) An exhaustive computational search of the ionic charge clusters mediating interactions between mammalian Cytochrome P450 (CYP450) and CYP450-Reductase. Computational Biology and Chemistry, 34, 42–52.

Blackburn JM & Shoko A (2010) Protein function microarrays for systems-oriented proteomic analysis. In Protein Microarrays: Methods in Molecular Biology (Korf U, ed). The Humana Press, Springer, NY.

Blackburn JM, Serufuri J-MS & Kumuthini J (2009) An in vitro method of cancer diagnosis. RSA patent 2009/05150

Dakshinamurthy A, Ramesar R, Goldberg P & Blackburn JM (2008) Infrequent and Low Expression of Cancer-Testis Antigens Located on the X Chromosome in Colorectal Cancer: Implications for Immunotherapy in South African Populations. Biotechnology Journal 3, 1417-1423.

Beeton-Kempen N, Shoko A, Blackburn J (2008) Personalising protein-drug interactions. Pure & Applied Chemistry 80, 1793–1802.

Zhi, Z-L, Laurent, N, Powell, AK, Karamanska, R, Fais, M, Voglmeir, J, Wright, A, Blackburn, JM, Crocker, PR, Russell, DA, Flitsch, S, Field, RA, & Turnbull, JE (2008) A Versatile Gold Surface Approach for Fabrication and Interrogation of Glycoarrays. ChemBioChem 9, 1568-1575.

Laurent N, Voglmeir J, Wright A, Blackburn J, Pham NT, Wong S, Gaskell SJ & Flitsch SL (2008)Enzymatic glycosylation of peptide arrays on gold surfaces. ChemBioChem 9, 883-887.

 

[Blackburn group members in bold]