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Dr. J. Claire Hoving BSc(Hons) MSc (Med) PhD (UCT)

AFGrica Unit

Claire Hoving

Wellcome Trust Intermediate Fellow in Public Health and Tropical Medicine, Senior Research Officer, AFGrica Unit and Associate Member of the Institute of Infectious Disease and Molecular Medicine (IDM), Faculty of Health Sciences, UCT

Claire Hoving is a basic immunologist and her research aims at understanding host immune responses to disease with a particular focus on HIV-related fungal infections. Fungal infections are often an overlooked clinical and public health issue. Pneumocystis jirovecii is an opportunistic fungal pathogen of immunocompromised hosts and is a common cause of pneumonia and death in patients with HIV/AIDS. There are very few researchers dissecting the mechanisms of fungal infections in Africa, yet research in this field will provide new insights into protective immunity and may lead to improved treatments for immunocompromised hosts.

 


Selected publications:

Hoving JC. Pneumocystis and interactions with host immune receptors. PloS Pathog. 2018 22;14(2):e1006807.

Hoving JC, Kolls JK. New advances in understanding the host immune response to Pneumocystis. Curr Opin Microbiol. 2017 Dec;40:65-71.

Schwartz IS, Lerm B, Hoving JC, et al. Emergomyces africanus in Soil, South Africa. Emerg Infect Dis. 2018 Feb;24(2):377-380.

Wilson* GJ, Marakalala* MJ, Hoving JC*, van Laarhoven A*, Drummond RA, Kerscher B, Keeton R, van de Vosse E, Ottenhoff TH, Plantinga TS, Alisjahbana B, Govender D, Besra GS, Netea MG, Reid DM, Willment JA, Jacobs M, Yamasaki S, van Crevel R, Brown GD. The C-type lectin receptor CLECSF8/CLEC4D is a key component of anti-mycobacterial immunity. Cell Host Microbe (2015) 17:252-259.

Hoving JC, Wilson GJ and Brown GD. Signalling C-type lectin receptors, microbial recognition and immunity. Cell Microbiol. (2014) 16;185-194. (review)

Hoving JC, Cutler AJ, Leeto M, Horsnell WGC, Dewals BG, Nieuwenhuizen NE, Brombacher F. Interleukin 13-mediated colitis in the absence of IL-4Rα signalling. Gut. 2017 Nov;66(11):2037-2039.

Hoving JC, Kirstein F, Nieuwenhuizen NE, Fick LC, Hobeika E, Reth M, Brombacher F. Immunoglobulin E-producing B lymphocytes mediate colitis in BALB/c mice. Gastroenterology (2012) Jan; 142(1): 96.

 


Contact details:

Room S306.1 Wernher & Beit South
Institute of Infectious Disease and Molecular Medicine
Faculty of Health Sciences
University of Cape Town
Observatory 7925
South Africa


Email:  Jennifer.hoving@uct.ac.za

 


Group members:

Nontobeko Mthembu (MSc)

Patricia Otieno (PhD Student)

Maxine Hoft (PhD Student)

Tshepiso Mbangiwa (PhD Student)

Dr Sumayah Salie (Postdoc)

Dr Lucian Duvenage (Postdoc)

 


Collaborations:

Gordon Brown (MRC Centre for Medical Mycology, Aberdeen fungal group, University of Aberdeen, UK)

Jay Kolls (Professor of Paediatrics and Immunology, University of Pittsburgh School of Medicine, USA)

Mark Nicol (Medical Microbiology, UCT, SA)

Heather Zar (Red Cross Children’s Hospital, UCT, SA)

Nelesh Govender (NICD, SA)

Ilan Schwartz (University of Alberta, Canada)

Alf Both (Stellenbosch University, SA)

Alexandre Alanio (Institute Pasteur, France)

Georgia Schäffer (Medical Biochemistry, UCT)

Frank Brombacher (Cytokines and disease group, UCT)

 

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